Robert A Casero Selected Research

Spermine Synthase

1/2022	Phenylbutyrate modulates polyamine acetylase and ameliorates Snyder-Robinson syndrome in a Drosophila model and patient cells.
1/2020	(R,R)-1,12-Dimethylspermine can mitigate abnormal spermidine accumulation in Snyder-Robinson syndrome.
12/2018	Polyamine Homeostasis in Snyder-Robinson Syndrome.

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.

Realize the full power of the drug-disease research graph!

Robert A Casero Research Topics

Disease

60	Neoplasms (Cancer) 10/2022 - 03/2002
17	Carcinogenesis 01/2020 - 02/2004
14	Breast Neoplasms (Breast Cancer) 11/2021 - 07/2003
11	Inflammation (Inflammations) 01/2020 - 08/2004
9	Colonic Neoplasms (Colon Cancer) 05/2022 - 11/2003
7	Carcinoma (Carcinomatosis) 01/2018 - 11/2003
6	Lung Neoplasms (Lung Cancer) 01/2017 - 08/2002
6	Colorectal Neoplasms (Colorectal Cancer) 01/2016 - 02/2006
6	Non-Small-Cell Lung Carcinoma (Carcinoma, Non-Small Cell Lung) 02/2012 - 03/2002
4	Stomach Neoplasms (Stomach Cancer) 01/2020 - 01/2005
4	Colitis 01/2018 - 08/2004
4	Infections 01/2018 - 08/2004
4	Gastritis 10/2016 - 11/2010
4	Wounds and Injuries (Trauma) 01/2014 - 03/2010
3	Snyder Robinson syndrome 01/2022 - 12/2018
3	Gliosis 11/2020 - 01/2018
3	Reperfusion Injury 01/2014 - 05/2003
2	Triple Negative Breast Neoplasms 11/2021 - 01/2020
2	Tuberous Sclerosis (Bourneville's Disease) 11/2020 - 01/2018
2	Neurodevelopmental Disorders 11/2020 - 01/2018
2	Prostatic Neoplasms (Prostate Cancer) 01/2020 - 05/2008
2	Intellectual Disability (Idiocy) 01/2020 - 12/2018
2	Leukemia 01/2018 - 10/2005
2	Adenoma (Adenomas) 01/2018 - 02/2004
2	Polyps 01/2018 - 02/2004
2	Adenomatous Polyposis Coli (Familial Adenomatous Polyposis) 01/2018 - 02/2004
2	Acute Kidney Injury (Acute Renal Failure) 01/2017 - 05/2003
2	Acute Myeloid Leukemia (Acute Myelogenous Leukemia) 03/2014 - 03/2012
2	Ischemia 01/2014 - 05/2003
1	African Trypanosomiasis (Nagana) 10/2022
1	Inborn Genetic Diseases (Disease, Hereditary) 01/2022
1	Atrophy 05/2021
1	Muscular Atrophy (Muscle Atrophy) 05/2021
1	Lymphoma (Lymphomas) 01/2021

Drug/Important Bio-Agent (IBA)

75	PolyaminesIBA 10/2022 - 03/2002
26	EnzymesIBA 11/2020 - 11/2003
17	SpermineIBA 06/2022 - 07/2003
13	Polyamine OxidaseIBA 01/2020 - 11/2003
13	SpermidineIBA 01/2020 - 07/2003
12	Ornithine Decarboxylase (Decarboxylase, Ornithine)IBA 11/2021 - 12/2003
10	N(1),N(11)-diethylnorspermineIBA 05/2022 - 03/2002
9	Pharmaceutical PreparationsIBA 10/2022 - 02/2004
8	Histones (Histone)IBA 01/2016 - 10/2005
7	Proteins (Proteins, Gene)FDA Link 10/2020 - 05/2003
6	Lysine (L-Lysine)FDA Link 03/2014 - 07/2010
6	ChromatinIBA 09/2012 - 05/2007
5	Antineoplastic Agents (Antineoplastics)IBA 10/2018 - 03/2002
5	Messenger RNA (mRNA)IBA 01/2007 - 05/2003
4	Eflornithine (Ornidyl)FDA Link 01/2020 - 08/2004
4	Oxidoreductases (Dehydrogenase)IBA 05/2019 - 07/2005
4	Histone Deacetylase InhibitorsIBA 06/2014 - 10/2005
4	DNA (Deoxyribonucleic Acid)IBA 01/2013 - 12/2004
3	Small Interfering RNA (siRNA)IBA 05/2022 - 12/2005
3	Spermine SynthaseIBA 01/2022 - 12/2018
3	(N(1),N(12))bis(ethyl)- 6,7- dehydrospermineIBA 01/2021 - 01/2017
3	Fluorouracil (Carac)FDA LinkGeneric 01/2021 - 01/2007
3	Cisplatin (Platino)FDA LinkGeneric 01/2021 - 05/2003
3	PutrescineIBA 11/2020 - 07/2004
3	Azacitidine (5 Azacytidine)FDA Link 01/2019 - 01/2011
3	Biomarkers (Surrogate Marker)IBA 12/2018 - 05/2003
3	CurcuminIBA 01/2018 - 12/2017
3	ArginaseIBA 10/2016 - 08/2004
3	CytokinesIBA 09/2012 - 12/2006
3	diamine N-acetyltransferase (spermidine acetyltransferase)IBA 01/2007 - 08/2004
3	Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)IBA 12/2006 - 08/2004
2	ProdrugsIBA 05/2022 - 01/2018
2	Glucose (Dextrose)FDA LinkGeneric 11/2021 - 06/2017
2	trans-sodium crocetinate (crocetin)IBA 11/2020 - 01/2018
2	RNA (Ribonucleic Acid)IBA 10/2020 - 11/2003
2	Mechanistic Target of Rapamycin Complex 1IBA 11/2018 - 01/2018
2	Interleukin-17 (Interleukin 17)IBA 01/2018 - 01/2016
2	Dextran SulfateIBA 01/2018 - 01/2012
2	CarcinogensIBA 01/2018 - 12/2017
2	Oncogene Proteins (Oncogene Protein)IBA 06/2017 - 11/2011
2	Histone DemethylasesIBA 01/2016 - 01/2012
2	ThioureaIBA 04/2015 - 09/2012
2	Urea (Carbamide)FDA LinkGeneric 04/2015 - 09/2012
2	MethyltransferasesIBA 01/2013 - 12/2009
2	Estrogen Receptor alphaIBA 11/2012 - 07/2006
2	GuanidinesIBA 09/2012 - 07/2010
2	BiguanidesIBA 09/2012 - 07/2010
2	AcetyltransferasesIBA 09/2012 - 02/2006
2	entinostat (MS 275)IBA 01/2011 - 10/2005
2	Reactive Oxygen Species (Oxygen Radicals)IBA 05/2008 - 12/2006
2	Sulindac (Copal)FDA LinkGeneric 02/2006 - 02/2004
1	Enzyme Inhibitors (Inhibitors, Enzyme)IBA 06/2022
1	Polo-Like Kinase 1IBA 05/2022
1	Biological ProductsIBA 05/2022
1	AcetylesteraseIBA 01/2022
1	Progesterone Receptors (Progesterone Receptor)IBA 11/2021
1	Estrogens (Estrogen)FDA Link 11/2021
1	AndrogensIBA 05/2021
1	Docetaxel (Taxotere)FDA Link 01/2021
1	Erlotinib Hydrochloride (CP 358,774)FDA Link 01/2021
1	Bevacizumab (Avastin)FDA Link 01/2021
1	Gemcitabine FDA Link 01/2021

Therapy/Procedure

22	Therapeutics 10/2022 - 12/2003
7	Drug Therapy (Chemotherapy) 10/2022 - 01/2012
6	Chemoprevention 01/2018 - 02/2004
1	Immunotherapy 10/2022